Pfam Information-PF00070.17

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Pfam Header

IDENTIFICATION: Pyr_redox
DEFINITION: Pyridine nucleotide-disulphide oxidoreductase
COMMENT: This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.

Pfam Reference(s)

MEDLINE AUTHOR TITLE PUBLICATION COMMENT
96398614 Mande SS, Sarfaty S, Allen MD, Perham RN, Hol WG; Protein-protein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase. Structure 1996;4:277-286.

Family Structure

0....|....10...|....20...|....30...|....40...|....50...|....60...|....70...|....80...|....90...|....100..|....110..|....120..|....130..|....140..|....150..|....160..|....170..|....180..|....190..|....200..|....210..|....220..|....230..|....240..|....250..|....260..|....270..|....280..|....290..|....300..|....310..|....320..|....330..|....340..|....350..|....360..|....370..|....380..|....390..|....400..|....410..|....420..|....430..|....440..|....450..|....460..|....470..|....480..|....490..|....500..|....510..|....520..|....530..|....540..|....550..|....560..|....570..|....580..|....590..|....600..|.........
STRUCTURE EEE.EECCSHHHHHHH.HHHHH..................................HHHH.HT..T....................................CC..E.E..E.....E....EC.............S.S...........S...........S.............CSS.............TTT........S...........CH............HH.............H................-.H..............CHHHTS..CHHHHH...HHHHH...............HH.........H.H.......HT............TTCEE...EC..S....C.C...E....E...........E........EE.........................ECECTTSECEEEEE....................E...............E..................E.ET.....T........S.........C............T...............SC........E..............EEE.......EESE.....E.EECC.C
ACCESSIBILITY 200.000033300100.01001..................................1124.02..4....................................01..4.0..0.....0....01.............5.3...........6...........2.............101.............255........1...........00............04.............2................-.0..............015210..104010...20315...............01.........1.5.......63............54041...23..4....1.4...1....4...........3........14.........................21447683212102....................0...............4..................1.44.....5........7.........5............5...............63........5..............245.......4031.....0.0013.3
CONSENSUS cls.llGuG.hGlEhA.thh......................................tp..h..G.....................................h..c.V..s.....l....lc.............t.t...........s...........p..............hh....................................................................................h...............tth.......h.........p..........................h.p.......pp.............slpl...hh..s....s.p...s....p...........p........lp............................tsp.t....lh....................h...............p...........................................................p...............tp........p..............lt.........s-h.....l.lhuh.G

Co-evolving pairs with Z>=4 and Sequence Distance > 10

MUTATION COUNT COL 1 H1 COL 2 H2 H12 MI SEQUENCE DISTANCE AVG DISTANCE STDEV AVG RANDOM DISTANCE STDEV
1172 17 3.902 591 3.941 7.387 0.455 85 11.7 0.8 30.7 11.9
1207 9 3.432 103 3.78 6.77 0.442 16 15.5 0.6 19.3 7.7
762 9 3.467 123 3.23 6.264 0.433 22 8.9 1.1 20.4 8.5

Z>=4 average 3D distance: 12 stdev: 3.3

Co-evolving pairs with Z=3 and Sequence Distance > 10

MUTATION COUNT COL 1 H1 COL 2 H2 H12 MI SEQUENCE DISTANCE AVG DISTANCE STDEV AVG RANDOM DISTANCE STDEV
1372 137 3.398 370 3.843 6.817 0.424 35 3.8 0.6 23.8 10.5
1154 2 2.553 589 3.083 5.216 0.42 96 3.6 0.2 30.6 12.5
1083 123 3.125 360 3.566 6.282 0.409 33 3.3 0.3 23.6 10.6
1017 9 3.419 591 3.936 6.947 0.408 92 15.1 0.8 31 12.1
672 13 2.526 123 3.289 5.411 0.404 18 11.1 0.5 20.2 8.1
1153 18 3.751 591 3.93 7.282 0.399 84 10.4 1.6 31.1 12.1
835 9 3.486 327 2.905 6.003 0.388 45 8 0.7 26.6 11.5
1329 103 3.681 591 3.908 7.211 0.378 76 6.7 1.2 30.7 11.9
847 17 3.965 352 2.698 6.288 0.375 43 8.4 0.6 25.8 10.8
784 9 3.537 65 2.793 5.955 0.375 14 16.9 0.2 19.3 7.2
842 17 3.965 601 2.499 6.096 0.368 89 10.9 1 31.5 12.3
898 18 3.859 352 2.595 6.086 0.368 42 10.2 0.6 25.9 11.2
1075 62 3.416 591 3.815 6.864 0.368 79 10.8 1.7 30.4 12.3

Z=3 average 3D distance: 9.2 stdev: 4.2

Download

Click to download File Size
MI: mi_pdb_PF00070.17_full_pfam.xml.gz 179 KB
Pfam: pdb_PF00070.17_full_pfam.xml.gz 313 KB

X3D PDB Models

The following X3D models currently only work with BS Contact for Windows. X3D is a new ISO standard and so not all VRML viewers have full support for the newer X3D features. Please see X3DPDB for additional information.

Click to download File Size
PDB: mi_pdb_PF00070.17_full_pfam_1dxl_D.x3d 147 KB
PDB: mi_pdb_PF00070.17_full_pfam_1dxl_C.x3d 146 KB
PDB: mi_pdb_PF00070.17_full_pfam_1dxl_B.x3d 146 KB
PDB: mi_pdb_PF00070.17_full_pfam_1mo9_B.x3d 164 KB
PDB: mi_pdb_PF00070.17_full_pfam_1dxl_A.x3d 146 KB
PDB: mi_pdb_PF00070.17_full_pfam_1mo9_A.x3d 163 KB
PDB: mi_pdb_PF00070.17_full_pfam_1xan_A.x3d 146 KB
PDB: mi_pdb_PF00070.17_full_pfam_1h6v_E.x3d 153 KB
PDB: mi_pdb_PF00070.17_full_pfam_1h6v_D.x3d 154 KB
PDB: mi_pdb_PF00070.17_full_pfam_1h6v_C.x3d 151 KB
PDB: mi_pdb_PF00070.17_full_pfam_1vdc_A.x3d 102 KB
PDB: mi_pdb_PF00070.17_full_pfam_1h6v_B.x3d 155 KB
PDB: mi_pdb_PF00070.17_full_pfam_1h6v_A.x3d 154 KB
PDB: mi_pdb_PF00070.17_full_pfam_1gsn_A.x3d 146 KB
PDB: mi_pdb_PF00070.17_full_pfam_3lad_B.x3d 148 KB
PDB: mi_pdb_PF00070.17_full_pfam_3lad_A.x3d 147 KB
PDB: mi_pdb_PF00070.17_full_pfam_1lpf_B.x3d 150 KB
PDB: mi_pdb_PF00070.17_full_pfam_1grb_A.x3d 145 KB
PDB: mi_pdb_PF00070.17_full_pfam_1lpf_A.x3d 149 KB
PDB: mi_pdb_PF00070.17_full_pfam_1q1w_B.x3d 133 KB
PDB: mi_pdb_PF00070.17_full_pfam_2grt_A.x3d 145 KB
PDB: mi_pdb_PF00070.17_full_pfam_1q1w_A.x3d 134 KB
PDB: mi_pdb_PF00070.17_full_pfam_1mok_C.x3d 164 KB
PDB: mi_pdb_PF00070.17_full_pfam_1jeh_B.x3d 149 KB
PDB: mi_pdb_PF00070.17_full_pfam_1mok_B.x3d 164 KB
PDB: mi_pdb_PF00070.17_full_pfam_1jeh_A.x3d 150 KB
PDB: mi_pdb_PF00070.17_full_pfam_1mok_A.x3d 162 KB
PDB: mi_pdb_PF00070.17_full_pfam_1q1r_B.x3d 133 KB
PDB: mi_pdb_PF00070.17_full_pfam_1q1r_A.x3d 133 KB
PDB: mi_pdb_PF00070.17_full_pfam_1gra_A.x3d 145 KB
PDB: mi_pdb_PF00070.17_full_pfam_1ebd_B.x3d 144 KB
PDB: mi_pdb_PF00070.17_full_pfam_1ebd_A.x3d 144 KB


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