Pfam Information-PF00047.15

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Pfam Header

IDENTIFICATION: ig
DEFINITION: Immunoglobulin domain
COMMENT: Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The Pfam alignments do not include the first and last strand of the immunoglobulin-like domain.

Pfam Reference(s)

MEDLINE AUTHOR TITLE PUBLICATION COMMENT
96159970 Bruemmendorf T, Rathjen FG; Cell adhesion molecules 1: immunoglobulin superfamily. Protein Profile 1995;2:963-1085.
95018199 Bork P, Holm L, Sander C; The immunoglobulin fold J Mol Biol 1994;242:309-320.
88251680 Williams AF, Barclay N; The immunoglobulin superfamily - domains for cell surface recognition. Annu Rev Immunol 1988;6:381-405.

Family Structure

0....|....10...|....20...|....30...|....40...|....50...|....60...|....70...|....80...|....90...|....100..|....110..|....120..|....130..|....140..|....150..|....160..|....170..|....180..|....190..|....200..|....210..|.......
STRUCTURE TCCE..EE...EEEEE........CEECSS.C...C...EEEE....EEE..CCECC.CCT......T..E.EC...C.EC......CEEC..EEEEETSE.EEEEECETTC.........................TCCET-ECECEE.........................TTTECEEEEC....SCCGGTGC...E...E...EE.EEE
ACCESSIBILITY 5350..30...20213........423434.4...2...3020....113..64225.465......6..6.54...4.54......4443..14434332.2233323374.........................64444-213433.........................6621111314....50446723...1...3...01.010
CONSENSUS Gpsl..sL...pCps............sss.....s...phpW....h......+.....s......s..p.th...t..p......tpht......tt.................................................................................Lhlp....sls.p.cu...G...p...Yp.Chs

Co-evolving pairs with Z>=4 and Sequence Distance > 10

MUTATION COUNT COL 1 H1 COL 2 H2 H12 MI SEQUENCE DISTANCE AVG DISTANCE STDEV AVG RANDOM DISTANCE STDEV
73 12 2.538 210 2.467 4.4 0.605 60 2.4 1.2 22 15.5
360 42 1.804 199 3.075 4.491 0.388 42 9.5 1.6 23.8 10.8
166 42 2.647 210 1.34 3.613 0.375 46 3.8 0.6 25.9 11.8
183 12 1.46 42 2.527 3.625 0.361 15 4.3 1.5 22.4 9.8

Z>=4 average 3D distance: 5 stdev: 3.1

Co-evolving pairs with Z=3 and Sequence Distance > 10

MUTATION COUNT COL 1 H1 COL 2 H2 H12 MI SEQUENCE DISTANCE AVG DISTANCE STDEV AVG RANDOM DISTANCE STDEV
288 12 1.06 199 3.415 4.154 0.321 56 13.9 1 22.7 13.8
573 180 2.807 199 2.366 4.859 0.314 12 11.5 3.4 21.3 8.7
291 42 2.024 207 2.107 3.82 0.311 44 4.5 1.3 25.4 11.4
888 0 2.858 194 2.911 5.464 0.304 61 9.3 6.2 22.6 15.1
657 0 3.374 199 2.149 5.22 0.304 63 13.9 5.1 24.6 15
783 0 3.088 180 2.38 5.168 0.3 52 13.7 2.4 24.9 12.8
211 12 1.303 207 2.399 3.409 0.293 58 8.5 1 22.2 14.8

Z=3 average 3D distance: 10.7 stdev: 3.6

Download

Click to download File Size
MI: mi_pdb_PF00047.15_full_pfam.xml.gz 70 KB
Pfam: pdb_PF00047.15_full_pfam.xml.gz 205 KB

X3D PDB Models

The following X3D models currently only work with BS Contact for Windows. X3D is a new ISO standard and so not all VRML viewers have full support for the newer X3D features. Please see X3DPDB for additional information.

Click to download File Size
PDB: mi_pdb_PF00047.15_full_pfam_1hdm_B.x3d 59 KB
PDB: mi_pdb_PF00047.15_full_pfam_1hdm_A.x3d 59 KB
PDB: mi_pdb_PF00047.15_full_pfam_1xed_E.x3d 38 KB
PDB: mi_pdb_PF00047.15_full_pfam_1cvs_C.x3d 69 KB
PDB: mi_pdb_PF00047.15_full_pfam_1xed_D.x3d 35 KB
PDB: mi_pdb_PF00047.15_full_pfam_1xed_C.x3d 36 KB
PDB: mi_pdb_PF00047.15_full_pfam_1nbq_B.x3d 66 KB
PDB: mi_pdb_PF00047.15_full_pfam_1xed_B.x3d 37 KB
PDB: mi_pdb_PF00047.15_full_pfam_1nbq_A.x3d 67 KB
PDB: mi_pdb_PF00047.15_full_pfam_1xed_A.x3d 37 KB
PDB: mi_pdb_PF00047.15_full_pfam_1ry7_B.x3d 69 KB
PDB: mi_pdb_PF00047.15_full_pfam_1s5i_B.x3d 70 KB
PDB: mi_pdb_PF00047.15_full_pfam_1nez_C.x3d 41 KB
PDB: mi_pdb_PF00047.15_full_pfam_1bih_B.x3d 123 KB
PDB: mi_pdb_PF00047.15_full_pfam_1bih_A.x3d 123 KB
PDB: mi_pdb_PF00047.15_full_pfam_1s9v_B.x3d 58 KB
PDB: mi_pdb_PF00047.15_full_pfam_1jl4_D.x3d 58 KB
PDB: mi_pdb_PF00047.15_full_pfam_1jhk_B.x3d 66 KB
PDB: mi_pdb_PF00047.15_full_pfam_1cdu_A.x3d 57 KB
PDB: mi_pdb_PF00047.15_full_pfam_1bqh_J.x3d 41 KB
PDB: mi_pdb_PF00047.15_full_pfam_1bqh_I.x3d 41 KB
PDB: mi_pdb_PF00047.15_full_pfam_1wiq_B.x3d 116 KB
PDB: mi_pdb_PF00047.15_full_pfam_1bqh_H.x3d 41 KB
PDB: mi_pdb_PF00047.15_full_pfam_1wiq_A.x3d 115 KB
PDB: mi_pdb_PF00047.15_full_pfam_1bqh_G.x3d 41 KB
PDB: mi_pdb_PF00047.15_full_pfam_1igy_D.x3d 137 KB
PDB: mi_pdb_PF00047.15_full_pfam_1dqt_D.x3d 39 KB
PDB: mi_pdb_PF00047.15_full_pfam_1dqt_C.x3d 39 KB
PDB: mi_pdb_PF00047.15_full_pfam_1dqt_B.x3d 39 KB
PDB: mi_pdb_PF00047.15_full_pfam_1dqt_A.x3d 39 KB
PDB: mi_pdb_PF00047.15_full_pfam_1rzj_B.x3d 59 KB
PDB: mi_pdb_PF00047.15_full_pfam_1o0v_B.x3d 101 KB
PDB: mi_pdb_PF00047.15_full_pfam_1ae6_B.x3d 70 KB
PDB: mi_pdb_PF00047.15_full_pfam_1o0v_A.x3d 101 KB
PDB: mi_pdb_PF00047.15_full_pfam_1rhf_B.x3d 57 KB
PDB: mi_pdb_PF00047.15_full_pfam_1rhf_A.x3d 57 KB
PDB: mi_pdb_PF00047.15_full_pfam_1g84_A.x3d 35 KB
PDB: mi_pdb_PF00047.15_full_pfam_1iil_H.x3d 70 KB
PDB: mi_pdb_PF00047.15_full_pfam_1iil_G.x3d 69 KB
PDB: mi_pdb_PF00047.15_full_pfam_1cl7_C.x3d 29 KB
PDB: mi_pdb_PF00047.15_full_pfam_1fq9_C.x3d 69 KB


JSPWiki: PF00047.15
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