Pfam Information-PF00018.16

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Pfam Header

IDENTIFICATION: SH3_1
DEFINITION: SH3 domain
COMMENT: SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.

Pfam Reference(s)

MEDLINE AUTHOR TITLE PUBLICATION COMMENT
12169629 Kami K, Takeya R, Sumimoto H, Kohda D; Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p. EMBO J 2002;21:4268-4276.

Family Structure

0....|....10...|....20...|....30...|....40...|....50...|....60...|....70...|....80...|....90...|....100..|....110..|....120..|....130..|....140..|....150..|....160..|....170..|....180..|....190..|....200..|....210..|....220..|....230..|....240..|....250..|....260..|.............
STRUCTURE CEEEES..S...C...B...CCCSHH.....CCCTT..BCSSTTCBC....C.B..CTT..........C...E..EE....E..............E...............EC..............C.....SSTS....CCTS............................E.EE...E.......E....E....TT...T.CT..CTS...............SCC.....E......EE..E....E.....GGG.EEEC..
ACCESSIBILITY 430203..4...5...1...726556.....55685..111069310....4.0..555..........2...4..03....1..............3...............45..............5.....6566....4654............................2.12...0.......3....1....66...6.65..479...............645.....5......02..0....0.....252.0444..
CONSENSUS .hshAl..a...s...a...pups..........ss..E.......L....s.h..pcG..........-...h..lp....l..............l...............pp..............s.....ss.........s............................W.ap...u.......c....h....p...........t..................p.....p......Gh..h....P.....ssY.Vp.h..

Co-evolving pairs with Z>=4 and Sequence Distance > 10

MUTATION COUNT COL 1 H1 COL 2 H2 H12 MI SEQUENCE DISTANCE AVG DISTANCE STDEV AVG RANDOM DISTANCE STDEV
62 175 2.637 253 1.572 3.712 0.497 17 4.2 5.7 16.7 6.7

Z>=4 average 3D distance: 4.2 stdev: 0

Co-evolving pairs with Z=3 and Sequence Distance > 10

MUTATION COUNT COL 1 H1 COL 2 H2 H12 MI SEQUENCE DISTANCE AVG DISTANCE STDEV AVG RANDOM DISTANCE STDEV
781 0 4.109 114 3.676 7.329 0.456 30 6 2.8 16.7 8.2
371 8 2.927 261 2.159 4.667 0.419 49 6 8.6 19.4 10.1
890 178 3.657 237 3.584 6.831 0.411 11 4 2.6 16.1 5.3
316 38 2.759 261 2.392 4.742 0.408 40 11.4 7.9 17.8 8.5

Z=3 average 3D distance: 6.8 stdev: 3.1

Download

Click to download File Size
MI: mi_pdb_PF00018.16_full_pfam.xml.gz 92 KB
Pfam: pdb_PF00018.16_full_pfam.xml.gz 132 KB

X3D PDB Models

The following X3D models currently only work with BS Contact for Windows. X3D is a new ISO standard and so not all VRML viewers have full support for the newer X3D features. Please see X3DPDB for additional information.

Click to download File Size
PDB: mi_pdb_PF00018.16_full_pfam_1shf_A.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_3sem_B.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_3sem_A.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_1hsq_A.x3d 24 KB
PDB: mi_pdb_PF00018.16_full_pfam_1t3s_A.x3d 94 KB
PDB: mi_pdb_PF00018.16_full_pfam_1spk_A.x3d 24 KB
PDB: mi_pdb_PF00018.16_full_pfam_3gbq_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1ujy_A.x3d 26 KB
PDB: mi_pdb_PF00018.16_full_pfam_1ugv_A.x3d 24 KB
PDB: mi_pdb_PF00018.16_full_pfam_1csk_D.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1csk_C.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_1csk_B.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1csk_A.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_1m27_C.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_2abl_A.x3d 52 KB
PDB: mi_pdb_PF00018.16_full_pfam_2hsp_A.x3d 24 KB
PDB: mi_pdb_PF00018.16_full_pfam_1ckb_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1awx_A.x3d 23 KB
PDB: mi_pdb_PF00018.16_full_pfam_4gbq_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1t3l_A.x3d 97 KB
PDB: mi_pdb_PF00018.16_full_pfam_1aww_A.x3d 23 KB
PDB: mi_pdb_PF00018.16_full_pfam_1cka_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1ksw_A.x3d 140 KB
PDB: mi_pdb_PF00018.16_full_pfam_1gfd_A.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_1t0h_A.x3d 33 KB
PDB: mi_pdb_PF00018.16_full_pfam_1s1n_A.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_1jo8_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1udl_A.x3d 32 KB
PDB: mi_pdb_PF00018.16_full_pfam_1uj0_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1bbz_G.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1bbz_C.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1k9a_E.x3d 138 KB
PDB: mi_pdb_PF00018.16_full_pfam_1k9a_D.x3d 135 KB
PDB: mi_pdb_PF00018.16_full_pfam_1bbz_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1fmk_A.x3d 136 KB
PDB: mi_pdb_PF00018.16_full_pfam_1k9a_C.x3d 137 KB
PDB: mi_pdb_PF00018.16_full_pfam_1k9a_B.x3d 138 KB
PDB: mi_pdb_PF00018.16_full_pfam_1gri_A.x3d 67 KB
PDB: mi_pdb_PF00018.16_full_pfam_1k9a_A.x3d 137 KB
PDB: mi_pdb_PF00018.16_full_pfam_1m30_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1aoj_B.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_1aoj_A.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_1oot_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1ark_A.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_2src_A.x3d 140 KB
PDB: mi_pdb_PF00018.16_full_pfam_1i0c_A.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_1ng2_A.x3d 57 KB
PDB: mi_pdb_PF00018.16_full_pfam_1jqq_D.x3d 25 KB
PDB: mi_pdb_PF00018.16_full_pfam_1io6_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1jqq_B.x3d 27 KB
PDB: mi_pdb_PF00018.16_full_pfam_1jeg_A.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_1jqq_A.x3d 27 KB
PDB: mi_pdb_PF00018.16_full_pfam_1g83_B.x3d 52 KB
PDB: mi_pdb_PF00018.16_full_pfam_1g83_A.x3d 52 KB
PDB: mi_pdb_PF00018.16_full_pfam_1h3h_A.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_1uec_A.x3d 57 KB
PDB: mi_pdb_PF00018.16_full_pfam_1m8m_A.x3d 19 KB
PDB: mi_pdb_PF00018.16_full_pfam_1awj_A.x3d 26 KB
PDB: mi_pdb_PF00018.16_full_pfam_1u06_A.x3d 19 KB
PDB: mi_pdb_PF00018.16_full_pfam_1sem_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1uhc_A.x3d 26 KB
PDB: mi_pdb_PF00018.16_full_pfam_1ov3_B.x3d 42 KB
PDB: mi_pdb_PF00018.16_full_pfam_1ov3_A.x3d 44 KB
PDB: mi_pdb_PF00018.16_full_pfam_1gbr_A.x3d 26 KB
PDB: mi_pdb_PF00018.16_full_pfam_1gbq_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1opl_A.x3d 140 KB
PDB: mi_pdb_PF00018.16_full_pfam_1gcq_B.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1gcq_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1oeb_A.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_1opk_A.x3d 139 KB
PDB: mi_pdb_PF00018.16_full_pfam_1m3c_A.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_1uti_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_2sem_B.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_2sem_A.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_1m3b_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1qly_A.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_1qkx_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1i07_B.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_1i07_A.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_1gl5_A.x3d 23 KB
PDB: mi_pdb_PF00018.16_full_pfam_2gbq_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1qkw_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1abo_B.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1abo_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1ue9_A.x3d 27 KB
PDB: mi_pdb_PF00018.16_full_pfam_1shg_A.x3d 20 KB
PDB: mi_pdb_PF00018.16_full_pfam_1n5z_C.x3d 24 KB
PDB: mi_pdb_PF00018.16_full_pfam_1n5z_A.x3d 24 KB
PDB: mi_pdb_PF00018.16_full_pfam_1neb_A.x3d 21 KB
PDB: mi_pdb_PF00018.16_full_pfam_1shf_C.x3d 21 KB


JSPWiki: PF00018.16
Your trail: HIVGENOME > T0288 > InfluenzaA > T0289 > MIQuaternary > PF04055.9 > HCV > PF00070.17 > PF00047.15 > PF00027.18
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